A method is provided for fine-grained detection of data modification of original data by associating separate guard bits with granules of memory storing original data from which translated data has been obtained. The guard bits indicating whether the original data stored in the associated granule is protected for data coherency. The guard bits are set and cleared by special-purpose instructions. Responsive to attempting access to translated data obtained from the original data, the guard bit(s) associated with the original data is checked to determine whether the guard bit(s) fail to indicate coherency of the original data, and if so, discarding of the translated data is initiated to facilitate maintaining data coherency between the original data and the translated data.