A transition minimized differential signaling (TMDS) receiver system including a clock channel, a plurality of data channels, a TMDS decoding unit, and a self-test unit is provided. The clock channel receives, processes and outputs a clock signal. Each data channel receives, processes and outputs a corresponding data signal according to the clock signal. The TMDS decoding unit receives and decodes the processed data signals. The self-test unit receives the clock signal and an external parallel signal, and accordingly, generates a test signal for performing the BIST on the data channels and the TMDS decoding unit. A BIST method adapted for the TMDS receiver system is also provided.