An automatic page-turning scan device for automatically turning and scanning pages of a book includes an automatic page-turning device and a scan module. The automatic page-turning device includes a base, a book support, a page-pressing module, a pick-up and page-turning module, and a system controller connected with the book support, the page-pressing module and the pick-up and page-turning module. The book support slidably mounted to the base includes two supporting panels for supporting the book. The page-pressing module is mounted to the supporting panel includes a driving module, and a pressing plate driven by the driving module. The pick-up and page-turning module mounted to the base includes a pick-up holder, a pick-up arm and a path guiding mechanism. The scan module is mounted to the automatic page-turning device, and the system controller controls the scan module to scan the pages of the book.