There is provided a seal structure for vehicle that includes a weather strip member 8 installed to a retainer member 9 provided to a circumference edge of a body aperture 7 and having a substantially “U” shape in section. The weather strip member 8 includes a primary seal lip 10 installed to an outer-cabin side surface part 9a of the retainer member 9 and makes a contact with an outer-cabin side surface 6b of a glass panel member 6, and a secondary seal lip 11 installed to an inner-cabin side surface part 9b and makes a contact with an inner-cabin side surface 6c of the glass panel member 6. The weather strip member 8 further includes a hollow seal part 12 installed near a bottom surface part 9c of the retainer member 9 and makes an elastic contact with an periphery end 6a of the glass panel member 6.