Invention Grant
- Patent Title: Double-acylated GLP-1 derivatives
- Patent Title (中): 双酰化GLP-1衍生物
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Application No.: US12970196Application Date: 2010-12-16
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Publication No.: US08648041B2Publication Date: 2014-02-11
- Inventor: Patrick William Garibay , Lars Linderoth , Jesper Lau , Per Sauerberg
- Applicant: Patrick William Garibay , Lars Linderoth , Jesper Lau , Per Sauerberg
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Richard W. Bork
- Priority: EP09179390 20091216
- Main IPC: A61K38/22
- IPC: A61K38/22 ; C07K14/575

Abstract:
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K37, and the second K residue is designated K26, which derivative comprises two albumin binding moieties attached to K26 and K37, respectively, wherein the albumin binding moiety comprises a protracting moiety selected from:Chem. 1, Chem. 2, Chem. 3 or Chem. 4; or a pharmaceutically acceptable salt, amide, or ester thereof.
Public/Granted literature
- US20110166321A1 DOUBLE-ACYLATED GLP-1 DERIVATIVES Public/Granted day:2011-07-07
Information query
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