Invention Grant
US08648051B2 Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
有权
富含G的寡核苷酸的抗增殖活性和使用其与核仁素结合的方法
- Patent Title: Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
- Patent Title (中): 富含G的寡核苷酸的抗增殖活性和使用其与核仁素结合的方法
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Application No.: US10978032Application Date: 2004-10-29
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Publication No.: US08648051B2Publication Date: 2014-02-11
- Inventor: Donald M. Miller , Paula J. Bates , John O. Trent
- Applicant: Donald M. Miller , Paula J. Bates , John O. Trent
- Applicant Address: US KY Louisville
- Assignee: Advanced Cancer Therapeutics, LLC
- Current Assignee: Advanced Cancer Therapeutics, LLC
- Current Assignee Address: US KY Louisville
- Agency: Dinsmore & Shohl LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04
Abstract:
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
Public/Granted literature
- US20090326047A1 Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin Public/Granted day:2009-12-31
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