Invention Grant
- Patent Title: Use of epicatechin and derivatives and salts thereof for cardiac protection of ischemic myocardium and to ameliorate adverse cardiac remodeling
- Patent Title (中): 表儿茶素及其衍生物及其盐用于缺血心肌的心脏保护，改善不良心脏重构
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Application No.: US12922170Application Date: 2009-03-12
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Publication No.: US08648059B2Publication Date: 2014-02-11
- Inventor: Francisco Villarreal , Katrina Go Yamazaki , Pam Rajendran Taub , Alan Maisel
- Applicant: Francisco Villarreal , Katrina Go Yamazaki , Pam Rajendran Taub , Alan Maisel
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Gavrilovich, Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr.
- International Application: PCT/US2009/036996 WO 20090312
- International Announcement: WO2009/114716 WO 20090917
- Main IPC: A61K31/65
- IPC: A61K31/65
Abstract:
The disclosure provides a method of reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof, wherein the subject is a human or a veterinary animal. Additionally the disclosure provides a method of treating subarachnoid hemorrhage or atrial fibrillation or of enhancing or preserving migration, seeding, proliferation, differentiation and/or survival of stem cells in injured heart tissue comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof. The effects of epicatechin administration are sustained over time.
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