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Invention Grant
US08648077B2 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid addition salt and salt crystals 有权
4 - （（6bR，10aS）-3-甲基-2,3,6b，9,10,10a-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3-de ]喹喔啉-8（7H） - 基）-1-（4-氟苯基）-1-丁酮甲苯磺酸加成盐和盐晶体

  • Patent Title: 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid addition salt and salt crystals
  • Patent Title (中): 4 - （（6bR，10aS）-3-甲基-2,3,6b，9,10,10a-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3-de ]喹喔啉-8（7H） - 基）-1-（4-氟苯基）-1-丁酮甲苯磺酸加成盐和盐晶体
  • Application No.: US12922056
    Application Date: 2009-03-12
  • Publication No.: US08648077B2
    Publication Date: 2014-02-11
  • Inventor: John Tomesch , Lawrence P. Wennogle
  • Applicant: John Tomesch , Lawrence P. Wennogle
  • Applicant Address: US NY New York
  • Assignee: Intra-Cellular Therapies, Inc.
  • Current Assignee: Intra-Cellular Therapies, Inc.
  • Current Assignee Address: US NY New York
  • Agency: Hoxie & Associates LLC
  • International Application: PCT/US2009/001608 WO 20090312
  • International Announcement: WO2009/114181 WO 20090917
  • Main IPC: A61K31/495
  • IPC: A61K31/495
4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid addition salt and salt crystals
Abstract:
The present invention relates to toluenesulfonic acid addition salt crystals of 4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-Hexahydro-1H-Pyrido[3′,4′:4,5]Pyrrolo[1,2,3-De]Quinoxalin-8(7H)-yl)-1-(4-Fluorophenyl)-1-Butanone, the method of making and using such crystals.
Abstract(Chinese):

本发明涉及4 - （（6bR，10aS）-3-甲基-2,3,6b，9,10,10a-六氢-1H-吡啶并[3'，4'：4]的甲苯磺酸加成盐晶体， 5]吡咯并[1,2,3-de]喹喔啉-8（7H） - 基）-1-（4-氟苯基）-1-丁酮，制备和使用这种晶体的方法。

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