Invention Grant
US08648087B2 N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
有权
N4-苯基 - 喹唑啉-4-胺衍生物和相关化合物作为用于治疗过度增殖性疾病的ErbB I型受体酪氨酸激酶抑制剂
- Patent Title: N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
- Patent Title (中): N4-苯基 - 喹唑啉-4-胺衍生物和相关化合物作为用于治疗过度增殖性疾病的ErbB I型受体酪氨酸激酶抑制剂
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Application No.: US12085048Application Date: 2006-11-15
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Publication No.: US08648087B2Publication Date: 2014-02-11
- Inventor: Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
- Applicant: Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
- Applicant Address: US CO Boulder
- Assignee: Array Biopharma, Inc.
- Current Assignee: Array Biopharma, Inc.
- Current Assignee Address: US CO Boulder
- Agency: McDermott Will & Emery LLP
- International Application: PCT/US2006/044431 WO 20061115
- International Announcement: WO2007/059257 WO 20070524
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/517 ; C07D239/72 ; C07D401/00
Abstract:
This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
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