Invention Grant
US08648116B2 Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
有权
包括作为MEK抑制剂的多晶型物的N-（芳基氨基）磺酰胺的衍生物以及组合物，使用方法及其制备方法
- Patent Title: Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
- Patent Title (中): 包括作为MEK抑制剂的多晶型物的N-（芳基氨基）磺酰胺的衍生物以及组合物，使用方法及其制备方法
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Application No.: US12671287Application Date: 2008-07-28
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Publication No.: US08648116B2Publication Date: 2014-02-11
- Inventor: Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
- Applicant: Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
- Applicant Address: US CA San Diego
- Assignee: Ardea Biosciences, Inc.
- Current Assignee: Ardea Biosciences, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Millen, White, Zelano & Branigan, P.C.
- International Application: PCT/US2008/071392 WO 20080728
- International Announcement: WO2009/018233 WO 20090205
- Main IPC: A61K31/185
- IPC: A61K31/185 ; C07C311/00
Abstract:
This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.
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