Invention Grant
US08648188B2 Preparation of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-adenine
有权
2-氯-9-（2'-脱氧-2'-氟-β-D-阿拉伯呋喃糖基） - 腺苷的制备
- Patent Title: Preparation of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-adenine
- Patent Title (中): 2-氯-9-（2'-脱氧-2'-氟-β-D-阿拉伯呋喃糖基） - 腺苷的制备
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Application No.: US13179259Application Date: 2011-07-08
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Publication No.: US08648188B2Publication Date: 2014-02-11
- Inventor: Julian Paul Henschke , Xiaoheng Zhang , Lijun Mei , Yung-Fa Chen
- Applicant: Julian Paul Henschke , Xiaoheng Zhang , Lijun Mei , Yung-Fa Chen
- Applicant Address: TW Tainan
- Assignee: Scinopharm Taiwan, Ltd.
- Current Assignee: Scinopharm Taiwan, Ltd.
- Current Assignee Address: TW Tainan
- Agency: VLP Law Group LLp
- Agent Enshan Hong; Kent H. Cheng
- Priority: CN201010224898 20100709
- Main IPC: C07H19/00
- IPC: C07H19/00 ; C07H19/19
Abstract:
A process for making clofarabine comprising: fluorinating a compound of formula VII wherein each R4 is independently a hydroxy protecting group, OR6 is a leaving group, with a fluorinating agent in the presence of guanidine carbonate to give a compound of formula VIII: wherein R4 is as defined above; and deprotecting the compound of formula VIII to give the clofarabine.
Public/Granted literature
- US20120010397A1 Preparation of 2-chloro-9-(2'-deoxy-2'-fluoro-Beta-D-arabinofuranosyl)-adenine Public/Granted day:2012-01-12
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