Invention Grant
- Patent Title: Activating agent for peroxisome proliferator activated receptor
- Patent Title (中): 过氧化物酶体增殖物激活受体的活化剂
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Application No.: US12937986Application Date: 2009-04-15
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Publication No.: US08648208B2Publication Date: 2014-02-11
- Inventor: Shogo Sakuma , Rie Takahashi , Hideki Nakamura
- Applicant: Shogo Sakuma , Rie Takahashi , Hideki Nakamura
- Applicant Address: JP Tokyo
- Assignee: Nippon Chemiphar Co. Ltd.
- Current Assignee: Nippon Chemiphar Co. Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Jones Day
- Priority: JP2008-105899 20080415
- International Application: PCT/JP2009/057946 WO 20090415
- International Announcement: WO2009/128558 WO 20091022
- Main IPC: C07D209/12
- IPC: C07D209/12 ; C07D209/18 ; A61K31/405
Abstract:
A compound represented by the formula (I) or a pharmacologically acceptable salt thereof is used as an activator of PPAR wherein each of R1 and R2 is hydrogen, C1-8 alkyl, C1-8 alkyl substituted with halogen, or the like; each of R3, R4, R5, and R6 is hydrogen, C1-8 alkyl, or the like; X is sulfur or the like; Y is oxygen, a bond, or the like; p is 0 or 1; A is oxygen, CH2, N—NH2, or the like; when p is 1, B is phenyl, which can have a substituent; when p is 0, B is a condensed ring such as benzisoxazole, which can have a substituent; m is an integer of 1 to 4; and n is an integer of 0 to 5.
Public/Granted literature
- US20110098480A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Public/Granted day:2011-04-28
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