Invention Grant
- Patent Title: Processes suitable for the preparation of salmeterol
- Patent Title (中): 适用于制备沙美特罗的方法
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Application No.: US12103999Application Date: 2008-04-16
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Publication No.: US08648214B2Publication Date: 2014-02-11
- Inventor: Vinayak G. Gore , Avinash C. Gaikwad , Maheshkumar Gadakar , Vinay Kumar Shukla
- Applicant: Vinayak G. Gore , Avinash C. Gaikwad , Maheshkumar Gadakar , Vinay Kumar Shukla
- Applicant Address: GB
- Assignee: Generics [UK] Limited
- Current Assignee: Generics [UK] Limited
- Current Assignee Address: GB
- Agency: Dorsey & Whitney LLP
- Priority: IN1298/MUM/2005 20051017; IN827/MUM/2006 20060531
- Main IPC: C07C211/00
- IPC: C07C211/00
Abstract:
The present invention relates to processes for the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.
Public/Granted literature
- US20080262267A1 NOVEL PROCESS Public/Granted day:2008-10-23
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