Optical fiber-based wireless systems and related components and methods are disclosed. The systems support radio frequency (RF) communications with clients over optical fiber, including Radio-over-Fiber (RoF) communications. The systems may be provided as part of an indoor distributed antenna system (IDAS) to provide wireless communication services to clients inside a building or other facility. The communications can be distributed between a head end unit (HEU) that receives carrier signals from one or more service or carrier providers and converts the signals to RoF signals for distribution over optical fibers to end points, which may be remote antenna units (RAUs). A microprocessor-based control system or systems may also be employed. The control systems may include one or more microprocessors or microcontrollers in one or more of the components of the system that execute software instructions to control the various components and provide various features for the optical fiber-based distributed antenna systems.