Invention Grant
- Patent Title: System and method of evaluation of stochastic interactions of a soluble ligand with a target cell population for optimization of drug design and delivery
- Patent Title (中): 评估可溶性配体与靶细胞群体的随机相互作用的系统和方法,以优化药物设计和递送
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Application No.: US11449648Application Date: 2006-06-09
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Publication No.: US08650017B2Publication Date: 2014-02-11
- Inventor: Oleg U. Kirnasovsky , Vladimir Vainstein , Yuri Kogan , Zvia Agur
- Applicant: Oleg U. Kirnasovsky , Vladimir Vainstein , Yuri Kogan , Zvia Agur
- Applicant Address: IL Ramat Gan
- Assignee: Optimata Ltd.
- Current Assignee: Optimata Ltd.
- Current Assignee Address: IL Ramat Gan
- Agency: Sughrue Mion, PLLC
- Main IPC: G06G7/48
- IPC: G06G7/48 ; G06G7/58 ; G01N33/48 ; G01N31/00

Abstract:
A computer system for recommending an optimal treatment protocol comprising a model of biological processes related to a disease. A treatment protocol generator generates a plurality of treatment protocols for treating a disease using drugs. A selector selects an optimal treatment protocol from the plurality of treatment protocols based on model. The model further comprises a pharmacokinetics macro module adapted to analyze interactions between a ligand and a population of target cells at a tissue level. The model further comprises a pharmacokinetics micro module adapted to analyze interactions between the ligand and a cell at an individual cell level. The pharmacokinetics micro module is adapted to model behavior of the ligand and receptors related to single cell level of ligand-cell interactions, as a stochastic process.
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