A wheelchair docking system is provided to prevent accidental movement of a wheelchair away from a transfer object, such as a bed or toilet, while a person is transferring between the wheelchair and the object. The system includes a latch assembly and a post assembly, one of each which is mounted on the wheelchair and on the transfer object. The latch assembly is moveable between an open position to receive and release the post assembly and a closed position to retain the post assembly. The latch assembly is biased to the closed position. A lock is provided in the latch assembly to hold the latch assembly in the open position. In an alternative embodiment, the post assembly has interchangeable parts for mounting on different objects, and a clamp which is opened and closed by a dual-function pivotal post member.