A drive structure for driving an upper thread wiper of a sewing machine is provided, wherein the upper thread wiper and a drive device for driving the upper thread wiper are disposed on the cantilever and located close to the end of the needle shaft. In addition to that the drive device simplifies relative motion transmission structure, the cooperative arrangement between the upper thread wiper and the drive device further improves the power transmission efficiency and stability. The upper thread wiper can be quickly and easily assembled onto or removed from the wiper arm through a quick release device. Moreover, the drive structure is further provided with a clutch device which is capable of effecting or interrupting power transmission as desired.