The present disclosure relates to refrigerants generally, and more specifically to nonflammable, non-ozone depleting mixtures of refrigerants that may be substituted for (HCFC R-22, R-407C, R-417A, R-502, R-402A, R-402B, R-404A, R-408A &R-507A) and usable in mineral oil systems. Among the most preferred embodiments of the present invention(s) are mixtures that are substitutes for these refrigerants, comprising about 35 to 65 weight percent R-125, and about 20 to 55 weight percent R-134a, and about 5 to 25 weight percent of R-143a and about 1 to 5 weight percent hydro component of (R-600 OR R-601) or combination, and about 2-10 weight percent of R-227ea the weight percentages of the components being weight percentages of the overall mixture.