Invention Grant
- Patent Title: Methods for diagnosing diseases and evaluating treatments therefor using PET
- Patent Title (中): 使用PET诊断疾病和评估治疗方法
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Application No.: US12451305Application Date: 2008-05-09
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Publication No.: US08652440B2Publication Date: 2014-02-18
- Inventor: Masanori Ichise
- Applicant: Masanori Ichise
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Bryan Cave LLP
- International Application: PCT/US2008/005994 WO 20080509
- International Announcement: WO2008/140779 WO 20081120
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14
Abstract:
The present invention relates to methods for determining whether a mammal has a disease, such as diabetes, using PET data analysis techniques. These methods include administering to a mammal a PET-compatible tracer, such as a radioligand specific for a vesicular monoamine transporter 2 (VMAT2) receptor, and measuring total functional β-cell capacity (volume) of the mammal's pancreas using PET data analysis techniques. Methods for tracking the efficacy of a treatment for diabetes, for evaluating the regeneration of β-cells in a pancreas, and for monitoring a patient with a transplanted pancreas are also provided.
Public/Granted literature
- US20100196274A1 Methods for Diagnosing Diseases and Evaluating Treatments Therefor Using Pet Public/Granted day:2010-08-05
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