Invention Grant
- Patent Title: Antibody-drug conjugates and methods
- Patent Title (中): 抗体 - 药物偶联物和方法
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Application No.: US12052938Application Date: 2008-03-21
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Publication No.: US08652479B2Publication Date: 2014-02-18
- Inventor: Allen J. Ebens, Jr. , Frederic S. Jacobson , Paul Polakis , Ralph H. Schwall , Mark X. Sliwkowski , Susan D. Spencer
- Applicant: Allen J. Ebens, Jr. , Frederic S. Jacobson , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Genentech, Inc.
- Agent Alex Andrus
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p I where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
Public/Granted literature
- US20080171040A1 ANTIBODY-DRUG CONJUGATES AND METHODS Public/Granted day:2008-07-17
Information query
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