Invention Grant
- Patent Title: Drug carrier and drug carrier kit for inhibiting fibrosis
- Patent Title (中): 用于抑制纤维化的药物载体和药物载体试剂盒
-
Application No.: US13439330Application Date: 2012-04-04
-
Publication No.: US08652526B2Publication Date: 2014-02-18
- Inventor: Yoshiro Niitsu , Junji Kato , Yasushi Sato
- Applicant: Yoshiro Niitsu , Junji Kato , Yasushi Sato
- Applicant Address: JP Osaka
- Assignee: Nitto Denko Corporation
- Current Assignee: Nitto Denko Corporation
- Current Assignee Address: JP Osaka
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: JP2004-382791 20041222
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K9/14 ; A61K31/07 ; C12N15/11 ; A61K38/18

Abstract:
An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
Public/Granted literature
- US08591953B2 Drug carrier and drug carrier kit for inhibiting fibrosis Public/Granted day:2013-11-26
Information query