Invention Grant
US08652785B2 Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1
失效
包括使用血红素结合蛋白1的内皮NO合成酶调节剂的筛选方法
- Patent Title: Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1
- Patent Title (中): 包括使用血红素结合蛋白1的内皮NO合成酶调节剂的筛选方法
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Application No.: US13131914Application Date: 2009-11-27
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Publication No.: US08652785B2Publication Date: 2014-02-18
- Inventor: Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
- Applicant: Alexandra Krog , Jochen Kruip , Paulus Wohlfart , Johann Gassenhuber , Kathrin Heermeier , Hartmut Strobel , Natalie Karst , Alexandra Ferrier , Christian Viskov
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Lathrop & Gage LLP
- Agent James H. Velema, Esq.
- Priority: EP08291148 20081204
- International Application: PCT/EP2009/065989 WO 20091127
- International Announcement: WO2010/063652 WO 20100610
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.
Public/Granted literature
- US20110306553A1 METHODS AND USES INVOLVING HEME BINDING PROTEIN 1 Public/Granted day:2011-12-15
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