Invention Grant
US08652797B2 Methods of NAD-dependent deacetylation of a lysine residue in a protein
有权
蛋白质中赖氨酸残基的NAD依赖性脱乙酰化的方法
- Patent Title: Methods of NAD-dependent deacetylation of a lysine residue in a protein
- Patent Title (中): 蛋白质中赖氨酸残基的NAD依赖性脱乙酰化的方法
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Application No.: US12209847Application Date: 2008-09-12
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Publication No.: US08652797B2Publication Date: 2014-02-18
- Inventor: Leonard Guarente , Shin-ichiro Imai , Christopher Armstrong
- Applicant: Leonard Guarente , Shin-ichiro Imai , Christopher Armstrong
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; C12N9/00
Abstract:
Methods of NAD-dependent of at least one lysine residue in an acetylated protein are disclosed. The methods include combining the acetylated protein with an isolated Sir2 protein or fragment that includes a core domain of the Sir2 protein. The Sir2 protein or fragment of the Sir2 protein can include a human Sir2 protein or a fragment of a human Sir2 protein.
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