Invention Grant
US08652837B2 Method and means for producing high titer, safe, recombinant lentivirus vectors
有权
生产高滴度，安全，重组慢病毒载体的方法和方法
- Patent Title: Method and means for producing high titer, safe, recombinant lentivirus vectors
- Patent Title (中): 生产高滴度，安全，重组慢病毒载体的方法和方法
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Application No.: US11781094Application Date: 2007-07-20
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Publication No.: US08652837B2Publication Date: 2014-02-18
- Inventor: Luigi Naldini , Thomas Dull , Anatoly Bukovsky , Deborah A. Farson , Rochelle Witt
- Applicant: Luigi Naldini , Thomas Dull , Anatoly Bukovsky , Deborah A. Farson , Rochelle Witt
- Applicant Address: US CT Greenwich
- Assignee: GBP IP, LLC
- Current Assignee: GBP IP, LLC
- Current Assignee Address: US CT Greenwich
- Agency: Jones Day
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/85
Abstract:
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
Public/Granted literature
- US20080241929A1 METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS Public/Granted day:2008-10-02
Information query
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