Invention Grant
US08653043B2 Enhanced neoglycosides through neoglycosylation and methods of use thereof
有权
通过新糖基化改善新糖苷配基及其使用方法
- Patent Title: Enhanced neoglycosides through neoglycosylation and methods of use thereof
- Patent Title (中): 通过新糖基化改善新糖苷配基及其使用方法
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Application No.: US13143639Application Date: 2010-01-07
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Publication No.: US08653043B2Publication Date: 2014-02-18
- Inventor: Randal D. Goff , Jon Scott Thorson
- Applicant: Randal D. Goff , Jon Scott Thorson
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- International Application: PCT/US2010/020300 WO 20100107
- International Announcement: WO2010/080863 WO 20100715
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H5/06
Abstract:
Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, based upon the appended sugar, into two distinct compound subsets.
Public/Granted literature
- US20120108530A1 Enhanced Neoglycosides Through Neoglycosylation and Methods of Use Thereof Public/Granted day:2012-05-03
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