Invention Grant
- Patent Title: Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
- Patent Title (中): 与神经元烟碱乙酰胆碱受体相互作用的双季铵环化合物
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Application No.: US12300197Application Date: 2007-05-11
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Publication No.: US08653275B2Publication Date: 2014-02-18
- Inventor: Peter Crooks , Linda P. Dwoskin , Guangrong Zheng , Sangeetha Sumithran , Davis D. Allen , Zhenfa Zheng , Paul Lockman
- Applicant: Peter Crooks , Linda P. Dwoskin , Guangrong Zheng , Sangeetha Sumithran , Davis D. Allen , Zhenfa Zheng , Paul Lockman
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky Research Foundation
- Current Assignee: University of Kentucky Research Foundation
- Current Assignee Address: US KY Lexington
- Agency: Crowell & Moring LLP
- International Application: PCT/US2007/011269 WO 20070511
- International Announcement: WO2007/133614 WO 20071122
- Main IPC: C07D211/68
- IPC: C07D211/68 ; A61K31/435
Abstract:
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
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