Invention Grant
US08653281B2 Process for the manufacture of agomelatine and its intermediate
有权
制备agomelatine及其中间体的方法
- Patent Title: Process for the manufacture of agomelatine and its intermediate
- Patent Title (中): 制备agomelatine及其中间体的方法
-
Application No.: US13056032Application Date: 2009-07-23
-
Publication No.: US08653281B2Publication Date: 2014-02-18
- Inventor: Guisen Zhang , Daopeng Chen , Yanqin Ma , Xiangping Yang , Shixia Zhou , Liang Chen
- Applicant: Guisen Zhang , Daopeng Chen , Yanqin Ma , Xiangping Yang , Shixia Zhou , Liang Chen
- Applicant Address: CN
- Assignee: NHWA Pharma. Corporation
- Current Assignee: NHWA Pharma. Corporation
- Current Assignee Address: CN
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Priority: CN200810020827 20080729
- International Application: PCT/CN2009/072886 WO 20090723
- International Announcement: WO2010/012208 WO 20100204
- Main IPC: C07D209/48
- IPC: C07D209/48
Abstract:
A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy- 1-naphthy)ethyl]phthalimide is provided and inclues reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1 -naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
Public/Granted literature
- US20110130571A1 PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE Public/Granted day:2011-06-02
Information query
