Invention Grant
US08653307B2 Liphagal enantiomers and their derivatives and precursors, and enantioselective methods of making the same
有权
双歧异对映体及其衍生物和前体，以及制备相同的对映选择性方法
- Patent Title: Liphagal enantiomers and their derivatives and precursors, and enantioselective methods of making the same
- Patent Title (中): 双歧异对映体及其衍生物和前体，以及制备相同的对映选择性方法
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Application No.: US13485835Application Date: 2012-05-31
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Publication No.: US08653307B2Publication Date: 2014-02-18
- Inventor: Brian M Stoltz , Ryan McFadden , Scott C. Virgil , Helene Kolding , Jennifer L Alleva , Joshua J Day
- Applicant: Brian M Stoltz , Ryan McFadden , Scott C. Virgil , Helene Kolding , Jennifer L Alleva , Joshua J Day
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Ropes & Gray LLP
- Agent David P. Halstead; David P. Pleynet
- Main IPC: C07C49/00
- IPC: C07C49/00
Abstract:
Enantioenriched compositions of liphagal and its derivatives and precursors include more than 50 mol % of a first enantiomer based on the total amount of a first and a second enantiomer. A method of making an enantioenriched composition includes catalytic enantioselective alkylation, ring expansion, and intramolecular aryne cyclization.
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