Processing a signal by receiving an analog input signal located outside of a first Nyquist zone that is between 0 and fs/2; passing the analog input signal through an M-channel time-interleaved analog-to-digital converter (TI-ADC) to generate a TI-ADC output signal; and estimating and correcting a timing skew error in the TI-ADC output signal. Alternatively, an electronic circuit that includes an input for an analog input signal, an M-channel time-interleaved analog-to-digital converter (TI-ADC) and a timing skew error estimating and correcting circuitry. The analog input signal is located outside of a first Nyquist zone that is between 0 and fs/2. The TI-ADC receives the analog input signal and generates a TI-ADC output signal. The timing skew error estimating and correcting circuitry estimates and corrects a timing skew error in the TI-ADC output signal.