A method, system, and computer usable program product for multiple threshold voltage cell families (mVt families) based integrated circuit design are provided in the illustrative embodiments. The integrated circuit includes cells, and a cell includes an electronic component. A design process is initialized by using cells from the mVt families in the design. The cells from the mVt families are included in iterative manipulation of the design. The cells from the mVt families are further included in violation cleanup and subsequent steps of the design process. A version of the design is produced that is usable to implement the circuit with the cells from the mVt families.