Methods, circuits, and systems for time encoder-based unmixing of hyperspectral imaging data are disclosed. A method of unmixing hyperspectral imaging data includes receiving mixed image data of one or more pixels. The mixed image data is generated by an imaging device that captures hyperspectral data. The mixed image data includes sensed spectral band intensities of materials in an area represented by a particular pixel. The mixed image data is converted from first analog domain signals into pulse domain signals. A solution to a mixing equation in the pulse domain is generated to identify abundances of one or more of the materials based on the sensed spectral band intensities. The sensed spectral band intensities are compared to reference spectral band intensities of a set of considered materials. The solution is converted from a pulse domain into an analog domain as second analog domain signals.