A novel central cooling and circulation energy management control system is provided, including an energy management controller device, a central cooling system, and associated methods, according to various embodiments. In one illustrative embodiment, a central cooling energy management controller device includes one or more signal connections, one or more electronic memory elements, and one or more processors. The controller device has access to resources that are either stored on the electronic memory elements or are accessible via the signal connections. The resources include an equipment data table, an equipment and operational configuration table, an operational efficiency matrix, and executable instructions. The processor determines operational control signals for energy-efficient operation of a central cooling system, based on sensor input from the central cooling system, and on data from the equipment data table, the equipment and operational configuration table, and the operational efficiency matrix; and provides the operational control signals via the signal connections.