A sealing device and a medicine packaging apparatus that includes the sealing device, wherein an engaging mechanism for coupling frames has good operability and the frames can firmly engage each other. The sealing device (10) can couple roller frames (20a, 20b) by an engaging mechanism (40) to integrate the roller frames. The engaging mechanism (40) has an engager (45) and a receptor (46) formed of a recess or the like. The engager includes a manipulation lever (50) and an engaging lever (51). The engager (45) is provided in the roller frame (20a), while the receptor (46) is provided in the roller frame (20b). When the manipulation lever (50) is pushed and pivoted toward the roller frame (20b), the engaging mechanism (40) can integrate the roller frames (20a, 20b). When the manipulation lever (50) is pulled and pivoted toward a front portion, the engaging mechanism can release the engagement caused by the engaging mechanism (40) to allow the roller frames (20a, 20b) to be separable from each other.