A device, system and method for capturing in-vivo images allows for size or distance estimations for objects within the images. According to one embodiment of the present invention there may be provided, in an in-vivo device at least an imager, an illumination source to provide illumination for the imager, an energy source to emit for example a light beam or a laser beam in a body lumen and a processor to, based on the light beam or laser beam image, estimate, for example the size of objects in a body lumen.