A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor.