[Problem to be solved] To provide a method for sterilizing powder or grain by which the heating time is a minimum required time to reduce thermal degradation of the quality of the powder or grain while securing sufficient sterilization effect, and a sterilizing apparatus employing the method.[Means to solve the problem]The problem is solved by a method for sterilizing powder or grain, and a sterilizing apparatus employing the method, and the method includes applying heat and pressure in which powder or grain is supplied into a heated gas flow pipe kept under heated and pressurized conditions, and the powder or grain is transferred while coming into direct contact with a heated condensable gas in the heated gas flow pipe for 0.008 to 2 seconds, and instantaneous reduced pressure sterilizing in which the heated condensable gas and the powder or grain are instantaneously released into a space having a pressure lower than that in the heated gas flow pipe, water contained in microorganisms adhering to the powder or grain is boiled rapidly, and tissues of the microorganisms are destroyed.