Invention Grant
- Patent Title: Protease screening methods and proteases identified thereby
- Patent Title (中): 因此鉴定出蛋白酶筛选方法和蛋白酶
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Application No.: US13507480Application Date: 2012-07-02
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Publication No.: US08663633B2Publication Date: 2014-03-04
- Inventor: Edwin L. Madison
- Applicant: Edwin L. Madison
- Applicant Address: US CA San Diego US CA South San Francisco
- Assignee: Torrey Pines Institute for Molecular Studies,Catalyst Biosciences, Inc.
- Current Assignee: Torrey Pines Institute for Molecular Studies,Catalyst Biosciences, Inc.
- Current Assignee Address: US CA San Diego US CA South San Francisco
- Agency: McKenna Long & Aldridge LLP
- Agent Stephanie Seidman
- Main IPC: A61K38/48
- IPC: A61K38/48 ; C12Q1/37 ; C07H21/04
Abstract:
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
Public/Granted literature
- US20120308551A1 Protease screening methods and proteases identified thereby Public/Granted day:2012-12-06
Information query
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