Invention Grant
- Patent Title: Solid dosage form for the ocular administration of an active principle, a soluble, solid ophthalmic insert and the production method thereof
- Patent Title (中): 用于眼部施用活性成分的固体剂型,可溶性固体眼科插入物及其制备方法
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Application No.: US10499058Application Date: 2002-12-17
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Publication No.: US08663678B2Publication Date: 2014-03-04
- Inventor: Saïd El Meski , Philippe Tourrette , Jean-Marc Aiache , Marie Di Battista , Gilbert Serpin
- Applicant: Saïd El Meski , Philippe Tourrette , Jean-Marc Aiache , Marie Di Battista , Gilbert Serpin
- Applicant Address: FR Clermont-Ferrand
- Assignee: Laboratoires Thea
- Current Assignee: Laboratoires Thea
- Current Assignee Address: FR Clermont-Ferrand
- Agency: Young & Thompson
- Priority: FR0116377 20011218
- International Application: PCT/FR02/04384 WO 20021217
- International Announcement: WO03/051330 WO 20030626
- Main IPC: A61K31/716
- IPC: A61K31/716 ; A61F2/00

Abstract:
A solid dosage form for the ocular administration of an active principle includes at least one biocompatible, water-soluble excipient for ophthalmic use. The form is obtained using a method which is selected from among the following: direct compression, dry compression, wet compression, compression of a lyophilizate, the compression being carried out a temperature below 45° C., or lyophilization, such that the form can disintegrate and release the active principle in the conjunctival sac. The invention also relates to an ophthalmic insert having the aforementioned dosage form which is appropriately dimensioned for ocular administration.
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