Invention Grant
US08664191B2 Use of two microRNA moleculars in lung cancer prognosis and medicine preparation
有权
在肺癌预后和药物制备中使用两种microRNA分子
- Patent Title: Use of two microRNA moleculars in lung cancer prognosis and medicine preparation
- Patent Title (中): 在肺癌预后和药物制备中使用两种microRNA分子
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Application No.: US13382686Application Date: 2009-07-09
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Publication No.: US08664191B2Publication Date: 2014-03-04
- Inventor: Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
- Applicant: Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
- Applicant Address: CN
- Assignee: Cancer Institute, Chinese Academy of Medical Services
- Current Assignee: Cancer Institute, Chinese Academy of Medical Services
- Current Assignee Address: CN
- Agency: Schwegman, Lundberg & Woessner, P.A.
- International Application: PCT/CN2009/072695 WO 20090709
- International Announcement: WO2011/003237 WO 20110113
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12Q1/68 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
Public/Granted literature
- US20120220644A1 USE OF TWO MICRORNA MOLECULARS IN LUNG CANCER PROGNOSIS AND MEDICINE PREPARATION Public/Granted day:2012-08-30
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