Invention Grant
- Patent Title: Benzodiazepine compound and pharmaceutical composition
- Patent Title (中): 苯二氮卓类化合物和药物组合物
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Application No.: US13591361Application Date: 2012-08-22
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Publication No.: US08664217B2Publication Date: 2014-03-04
- Inventor: Kunio Oshima , Takashi Oshiyama , Shinichi Taira , Yasuhiro Menjo , Hokuto Yamabe , Shuuji Matsumura , Masataka Ueda , Yasuo Koga , Kuninori Tai , Sunao Nakayama , Toshiyuki Onogawa , Kenji Tsujimae
- Applicant: Kunio Oshima , Takashi Oshiyama , Shinichi Taira , Yasuhiro Menjo , Hokuto Yamabe , Shuuji Matsumura , Masataka Ueda , Yasuo Koga , Kuninori Tai , Sunao Nakayama , Toshiyuki Onogawa , Kenji Tsujimae
- Applicant Address: JP Tokyo
- Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2008-041296 20080222; JP2008-227368 20080904
- Main IPC: C07D243/12
- IPC: C07D243/12 ; C07D401/12 ; C07D401/14 ; C07D491/04 ; C07D405/14 ; C07D417/14
Abstract:
The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
Public/Granted literature
- US20130040941A1 BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION Public/Granted day:2013-02-14
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