Invention Grant
US08664221B2 Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
失效
通过给予含有其中引入了磺酸酯结构的苯基的1,2,3,4-四氢喹喔啉化合物作为取代基来治疗炎性疾病的方法
- Patent Title: Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
- Patent Title (中): 通过给予含有其中引入了磺酸酯结构的苯基的1,2,3,4-四氢喹喔啉化合物作为取代基来治疗炎性疾病的方法
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Application No.: US13063186Application Date: 2009-09-11
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Publication No.: US08664221B2Publication Date: 2014-03-04
- Inventor: Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
- Applicant: Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
- Applicant Address: JP Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Holtz Holtz Goodman & Chick PC
- Priority: JP2008-234105 20080912
- International Application: PCT/JP2009/065888 WO 20090911
- International Announcement: WO2010/029986 WO 20100318
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A01N43/60 ; A61K31/495 ; A61K31/50 ; C07D241/36

Abstract:
The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R1 represents a group represented by general formula (2a), (3a), (4a) or (5a); R2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like; R3 represents a lower alkyl group; R4, R5, R6 or R7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; and m, n, p or q represents a number of 0, 1 or 2.
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