Invention Grant
US08664242B2 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
有权
8-氮杂双环[3.2.1]辛烷化合物作为μ阿片受体拮抗剂
- Patent Title: 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
- Patent Title (中): 8-氮杂双环[3.2.1]辛烷化合物作为μ阿片受体拮抗剂
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Application No.: US13527942Application Date: 2012-06-20
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Publication No.: US08664242B2Publication Date: 2014-03-04
- Inventor: Daniel D. Long , John R. Jacobsen , Lan Jiang
- Applicant: Daniel D. Long , John R. Jacobsen , Lan Jiang
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D451/02
![8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists](/abs-image/US/2014/03/04/US08664242B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Public/Granted literature
- US20130158060A1 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS Public/Granted day:2013-06-20
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