Invention Grant
US08664257B2 Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
有权
氧取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
- Patent Title: Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
- Patent Title (中): 氧取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
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Application No.: US13575008Application Date: 2011-01-26
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Publication No.: US08664257B2Publication Date: 2014-03-04
- Inventor: Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Bodo Scheiper , Klaus Wirth
- Applicant: Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Bodo Scheiper , Klaus Wirth
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP10305080 20100126
- International Application: PCT/EP2011/051038 WO 20110126
- International Announcement: WO2011/092187 WO 20110804
- Main IPC: C07D231/20
- IPC: C07D231/20 ; C07D231/22 ; C07D401/04 ; C07D401/12
Abstract:
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20130046004A1 OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2013-02-21
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