Invention Grant
- Patent Title: Nitroglycerin therapy for those unable to metabolize nitroglycerin
- Patent Title (中): 硝酸甘油治疗无法代谢硝酸甘油的人
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Application No.: US11594214Application Date: 2006-11-08
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Publication No.: US08664269B2Publication Date: 2014-03-04
- Inventor: Jonathan S. Stamler , Gregory T. Went
- Applicant: Jonathan S. Stamler , Gregory T. Went
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Bacon & Thomas, PLLC
- Main IPC: A61K31/21
- IPC: A61K31/21 ; A61K31/195
Abstract:
Those in need of nitroglycerin (GTN) therapy who have polymorphism in the mtALDH gene, e.g., those of Asian descent for whom this polymorphism is common, and/or who are being treated with or ingesting or exposed to mtALDH inhibitor are treated with GTN in combination with agent which converts GTN to product which is metabolized without mtALDH activity, e.g., N-acetylcysteine.
Public/Granted literature
- US20070123585A1 Nitroglycerin therapy for those unable to metabolize nitroglycerin Public/Granted day:2007-05-31
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