Invention Grant
US08664272B2 Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
有权
用于治疗骨髓增生异常综合征和急性骨髓性白血病的组合物和方法
- Patent Title: Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
- Patent Title (中): 用于治疗骨髓增生异常综合征和急性骨髓性白血病的组合物和方法
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Application No.: US12310575Application Date: 2006-08-30
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Publication No.: US08664272B2Publication Date: 2014-03-04
- Inventor: E. Premkumar Reddy , M. V. Ramana Reddy , James F. Holland , Lewis R. Silverman , Svetlana Zinzar
- Applicant: E. Premkumar Reddy , M. V. Ramana Reddy , James F. Holland , Lewis R. Silverman , Svetlana Zinzar
- Applicant Address: US PA Philadelphia US NY New York
- Assignee: Temple University—Of the Commonwealth System of Higher Education,Icahn School of Medicine at Mount Sinai
- Current Assignee: Temple University—Of the Commonwealth System of Higher Education,Icahn School of Medicine at Mount Sinai
- Current Assignee Address: US PA Philadelphia US NY New York
- Agency: Drinker Biddle & Reath LLP
- International Application: PCT/US2006/034093 WO 20060830
- International Announcement: WO2008/027049 WO 20080306
- Main IPC: C07C317/10
- IPC: C07C317/10 ; C07C229/34 ; C07C317/28
Abstract:
Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20100305059A1 COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA Public/Granted day:2010-12-02
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