Invention Grant
- Patent Title: Chemical linkers with single amino acids and conjugates thereof
- Patent Title (中): 具有单一氨基酸的化学接头及其共轭物
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Application No.: US12528316Application Date: 2008-02-20
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Publication No.: US08664407B2Publication Date: 2014-03-04
- Inventor: Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Nils Lonberg , Qian Zhang
- Applicant: Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Nils Lonberg , Qian Zhang
- Applicant Address: US NJ Princeton
- Assignee: Medarex, LLC
- Current Assignee: Medarex, LLC
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- International Application: PCT/US2008/054362 WO 20080220
- International Announcement: WO2008/103693 WO 20080828
- Main IPC: C07D403/00
- IPC: C07D403/00 ; C07D209/56 ; C12N5/071 ; A61K31/497 ; A61K31/40
Abstract:
The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
Public/Granted literature
- US20100113476A1 CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF Public/Granted day:2010-05-06
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