An LED control circuit with auto ON/OFF function has a power module, a control module, a timer module, a driver module and an LED module with a first LED unit and a second LED unit. The control module generates a time control signal and an LED control signal to respectively activate the timer module and the LED module. The LED module is activated by the LED control signal only when the timer module is turned ON. The timer module can be automatically turned ON/OFF by the time control signal. Moreover, the LED control signal has high potentials and low potentials. The driver module activates the first LED unit and the second LED unit based on two the different potentials of the LED control signal respectively. Both high and low potentials of the LED control are used. The performance of the LED module is improved.