A diffusion imaging method is provided. The diffusion imaging method includes performing a plurality of data collection sequences. Each data collection sequence includes applying an excitation radio frequency signal and a selection gradient. The excitation radio frequency signal includes a first set of frequency bands selected to simultaneously excite a first nuclei type in a plurality of cross sections of a subject. Each data collection sequence further includes applying a diffusion gradient during formation of a magnetic resonance signal, applying a spatial encoding gradient during formation of the magnetic resonance signal, and while acquiring the magnetic resonance signal, applying a separation gradient to change a frequency separation between portions of the magnetic resonance signal. The diffusion imaging method further includes computationally determining a diffusion image of each of the plurality of cross sections.