Apparatus and methods for amplifier power supply control are provided. In certain implementations, an amplifier includes an input amplification stage and a power supply control block for generating a power high supply and a power low supply for the input amplification stage. The power supply control block receives a reference signal indicative of a common-mode input voltage of the amplifier, and the power supply control block adjusts a voltage level of the power high and power low supplies while maintaining a substantially constant voltage difference between the power high and power low supplies. The power supply control block changes the voltage level of the power high and power low supplies based on the reference signal such that the voltage levels of the power high and power low supplies move in relation to the common-mode input voltage.