Invention Grant
US08666718B2 Structure of the C-terminal region of the insulin receptor α-chain and of the insulin-like growth factor receptor α-chain
有权
胰岛素受体α链和胰岛素样生长因子受体α链的C-末端区域的结构
- Patent Title: Structure of the C-terminal region of the insulin receptor α-chain and of the insulin-like growth factor receptor α-chain
- Patent Title (中): 胰岛素受体α链和胰岛素样生长因子受体α链的C-末端区域的结构
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Application No.: US13265879Application Date: 2010-03-09
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Publication No.: US08666718B2Publication Date: 2014-03-04
- Inventor: Michael Colin Lawrence , Brian John Smith , John Gerbrandt Tasman Menting , Colin Wesley Ward
- Applicant: Michael Colin Lawrence , Brian John Smith , John Gerbrandt Tasman Menting , Colin Wesley Ward
- Applicant Address: AU Parkville, Victoria
- Assignee: The Walter and Eliza Hall Institute of Medical Research
- Current Assignee: The Walter and Eliza Hall Institute of Medical Research
- Current Assignee Address: AU Parkville, Victoria
- Agency: Klauber & Jackson LLC
- International Application: PCT/AU2010/000271 WO 20100309
- International Announcement: WO2010/121288 WO 20101028
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G06G7/58
Abstract:
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
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